Contact us today download our full generic api product sheet. Chlordiazepoxide, 7chloro2methylamino5phenyl3 h1,4benzodiazepin4oxide 5. Chlordiazepoxide hcl is discontinued dea controlled substance. Diagnostic and statistical manual of mental disorders, ed 3. Usp chlordiazepoxide rs standard deviation for replicate injections is not more than usp chlordiazepoxide related compound a rs 2. Risks from concomitant use with opioids respiratory. Ndcs and labelers of chlordiazepoxide hydrochloride. Restricting the conformational freedom of the neuronal nitricoxide. Chlordiazepoxide hydrochloride, 438415, manufacturer. Librax chlordiazepoxide hydrochlorideclidinium bromide. Chlordiazepoxide c16h14cln3o cid 2712 structure, chemical names. Chlordiazepoxide hydrochloride is 7chloro2methylamino5phenyl3 h 1,4benzodiazepine 4oxide hydrochloride. Chlordiazepoxide hcl, capsule, 25 mg1, oral, watson pharmaceuticals.
It is unstable in solution and the powder must be protected from light. Jan 05, 2021 chlordiazepoxide and clidinium can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. Misuse of chlordiazepoxide and clidinium can cause addiction, overdose, or death. If you can not locate your required intermediate for chlordiazepoxide hydrochloride cas no 438415 on this page, you may send us a sourcing request for the specific chlordiazepoxide hydrochloride cas no 438415 intermediate you are looking for along with its cas no. A disclosed method for preparing chlordiazepoxide hydrochloride with small hygroscopicity comprises the following steps. Chlordiazepoxide hydrochloride drugspharmaceuticals with. Simultaneous hplc determination of chlordiazepoxide and.
There was a significantly higher odds ratio for chlordiazepoxide use during the second and third months of gestation in those with congenital cardiovascular malformations. Jan similar structures search, synonyms, formulas, resource links, and other chemical information. Dec 07, 2005 chlordiazepoxide hydrochloride is the prototype for the benzodiazepine compounds. Chlordiazepoxide hydrochloride c16h15cl2n3o pubchem. This product contains a chemical known to the state of california to cause birth defects or other reproductive harm. Librium is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hcl.
Chlordiazepoxide binds to stereospecific benzodiazepine bzd binding sites on. Small molecule cdmo generic apis list api products cambrex. This is reacted in the usual manner with hydroxylamine, forming 2amino5chlorobenzophenone oxide 5. The list of intermediates for chlordiazepoxide hydrochloride cas no 438415 will be updated soon. Chlordiazepoxide may cause a falsepositive pregnancy test, depending on method used. A simple, rapid, and sensitive rphplc method was developed and validated for the simultaneous determination of chlordiazepoxide cdo and mebeverine hcl mbv in the presence of cdo impurity 2amino5chlorobenzophenone, acb and mbv degradation product veratric acid, ver. Also, sdspage showed there were negligible amounts of. Chlordiazepoxide hydrochloride and clidinium bromide. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. Cn105294582a method for preparing chlordiazepoxide. Empirical formula hill notation c 16 h 14 cln 3 o hcl. Dispose of contaminated material as waste according to item.
Chlorine safety data sheet p4580 this sds conforms to u. This product is a sedative and hypnotic medication of the benzodiazepine class. Chlordiazepoxide hydrochloride is unstable in water, 0. Chlordiazepoxide, trade name librium among others, is a sedative and hypnotic medication of the benzodiazepine class. Chlordiazepoxide had been used during pregnancy in 201 cases 0. A white to practically white crystalline substance, it is soluble in water. Chlordiazepoxide hydrochloride oral route proper use mayo. Chlordiazepoxide hydrochloride oral route before using. Chlordiazepoxide hydrochloride is 7chloro2methylamino5phenyl3h1,4benzodiazepine 4oxide hydrochloride. Chlordiazepoxide has a medium to long halflife but its active metabolite has a very long halflife. Chlordiazepoxide hydrochloride 438415 19891201 new jersey right to know components chlordiazepoxide hydrochloride casno. Slightly hazardous in case of skin contact sensitizer. Chlordiazepoxide hydrochloride and clidinium bromide capsules.
Each capsule also contains corn starch, lactose and talc. The structural formula of chlordiazepoxide hydrochloride is as follows. Dailymed librax chlordiazepoxide hydrochloride and. Chlordiazepoxide hydrochloride proposition 65 warnings website. Expired lifetime application number us145782a inventor carstensen jens thuroe. Search results for chlordiazepoxide d5 at sigmaaldrich. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Does chlordiazepoxide hcl interact with other medications. Drug name active ingredients strength dosage formroute marketing status rld te code application no. Each capsule, for oral administration, contains either 5 mg, 10 mg or 25 mg of chlordiazepoxide hydrochloride, usp and has the following inactive ingredients. Sds of chlordiazepoxide hydrochloride, safety data sheets.
Hydrochloridemelting point boiling point density,438415 chlordiazepoxide hydrochloride cas chemical properties msds. A colorless, crystalline substance, it is soluble in water. Safety data sheet according to 29cfr19101200 and ghs rev. Chlordiazepoxide hydrochloride is the hydrochloride salt form of chlordiazepoxide, a longacting benzodiazepine with anxiolytic, sedative and hypnotic activity. Chlordiazepoxide fda prescribing information, side effects. Similarly, it may impair mental alertness in children. Chlordiazepoxide hydrochloride exerts its effect by binding to the benzodiazepine site at the gammaaminobutyric acid receptorchloride ionophore complex in the central nervous.
We incubated the clss in 50 mm trishcl, 150 mm nacl. Warnings chlordiazepoxide hcl may impair the mental andor physical abilities required for the performance of potentially hazardous tasks such as driving a vehicle or operating machinery. Libtrax tabletscapsules, taj pharma, libtrax side effects. Chlordiazepoxide hydrochloride and clidinium bromide drugs. Chlordiazepoxide hcl capsules are contraindicated in patients with known hypersensitivity to the drug. Safety data sheet in accordance with regulation ec no 19072006, as amended. Keep the medication in a place where others cannot get to it. Librax combines in a single capsule formulation the antianxiety action of chlordiazepoxide hydrochloride and the anticholinergicspasmolytic effects of clidinium. Bupivacaine hcl local anesthetic chlordiazepoxide base tranquilizer chlordiazepoxide hcl tranquilizer chlormadinone acetate progestogen antineoplastic chlorothiazide diuretic clobazam anxiolytic, anticonvulsant clonazepam antiepileptic clorazepate dipotassium antidepressant clozapine neuroleptic cromolyn sodium antiallergic. It may also alter urinary 17ketosteroids zimmerman reaction, urine alkaloid determination frings thin layer chromatography method, and urinary glucose determinations with chemstrip ug and diastix, but not glucose enzymatic test strip. Chlordiazepoxide hydrochloride, clidinium bromide chlordiazepoxide, clidiniumlibrax oral cap.
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